A Novel Approach to Protect Photoreceptors and RPE Integrity to Slow Geographic Atrophy Progression
Time: 4:30 pm
day: Day1
Details:
- Exploring the emerging role of ferroptosis — an iron-dependent, lipid peroxidation-driven form of programmed cell death — in retinal pigment epithelium (RPE) and photoreceptor degeneration in dry AMD
- Highlighting the therapeutic potential of transferrin, the primary iron-transport protein, to restore iron homeostasis and mitigate oxidative stress, dysregulated lipid metabolism, inflammation, complement activation, and ferroptosis
- Presenting Phase I trial for PST-611, a novel non-viral gene therapy delivered via a proprietary electrotransfection system, designed to locally provide sustained levels of transferrin
