Pre-Conference Workshop Day

Looking Ahead: Visual & Anatomical Endpoints to Enable Future Trials of AMD - Tuesday, 19 October 2021

10.00am -12.30pm EST | 4.00pm-6.30pm CEST

Looking Ahead: Visual & Anatomical Endpoints to Enable Future Trials of AMD

Ophthalmologists and retina specialists now have a wide range of
assessments available for the functional and anatomic characterization of GA in patients with AMD.

To date, studies have been limited by their unimodal approach and we recommend that future studies of GA use multimodal imaging. We also suggest strategies for the optimal functional testing of patients with GA.

  • Assess Biomarkers, Functional Outcomes & Clinically Relevant Endpoints in Dry AMD
  • Evaluate functional clinical endpoints and their structural correlations in AMD
  • Learn about overcoming challenges with visual and anatomical endpoints and how use these strategies to enable future successful trials of AMD

Workshop Leaders:

victor chong

Victor Chong

Global Head of Medicine
Retinal Health Boehringer Ingelheim International

david boyer

David Boyer

Senior Partner
Retina-Vitreous Associates Medical Group

Sobha Sivaprasad

Sobha Sivaprasad
Professor & Consultant Ophthalmologist
Moorfields Eye Hospital

New Concepts of AMD Pathophysiology Arising from Histologically Validated Clinical Imaging - Tuesday, 19 October 2021

1.30pm-4pm | 7.30pm-4pm CEST

The past decade has witnessed a revolution in retinal imaging providing detailed views of retinal changes in people who have age-related macular degeneration (AMD). New retinal imaging techniques have been driven by advances in optics, cameras, computers, and software, and have become extremely helpful guides for the diagnosis and treatment of AMD.

  • Understand how the underlying degeneration of AMD is uniquely approachable due to the remarkable precision of retinal neurons and support cells, availability of human tissue specimens for histology, clarity of eye’s optics, and the wealth of imaging data available from the management of anti-VEGF therapy for neovascularization
  • Examine Optical Coherence Tomography (OCT) as a clinical imaging technology that provides depth-resolved views of retinal and choroidal tissue layers. The multilayer progression sequence provided by eye-tracked OCT and histology has revolutionized models of how AMD begins and evolves
  • Review how end-stage atrophy and neovascularization are driven by two layers of extracellular deposits linked to cone- and rod-specific physiology, which accumulate during aging due to microangiopathy of choriocapillaris
  • Understand how RPE lipofuscin, the signal source for fundus autofluorescence imaging, can be re-imagined as a reporter of outer retinal metabolic status, rather than a toxic agent

Workshop Leader:

Christine Curcio

Christine Curcio Professor
Ophthalmology & Director, Age- Related Maculopathy Histopathology Lab
University of Alabama at Birmingham