Novel Non-Invasive Retinal Imaging Biomarkers to Precede Geographic Atrophy
Time: 1:10 pm
day: Workshop Day
Details:
Geographic atrophy includes photoreceptor depletion, reactive gliosis, and adhesion of retina to underlying tissue. Novel biomarkers are required for fast and accurate detection of disease stages earlier than atrophy. Current biomarkers for dry AMD include the presence and size of visible drusen deposits. However, drusen dynamism and the lack of methods for invisible drusen material limit their use as biomarkers. Recent histology defining the atrophy border in the neurosensory retina and validating OCT reflectivity make it possible to consider new methods, such as ellipsoid zone reflectivity, hypertransmission, and fundus autofluorescence.
Join this workshop to:
- Explore methods for imaging ellipsoid zone reflectivity and thickness, and understand their significance in evaluating retinal health
- Learn about emerging biomarkers, like hypertransmission defects that are valuable indicators of RPE dysfunction, identified through natural history studies, which serve as reliable precursors to geographic atrophy
- Learn about current biomarkers related to the retinal pigment epithelium health, emphasizing that the RPE can remain healthy up to intermediate stages of disease
- Utilizing OCT imaging and colour fundus photography to measure subretinal drusenoid deposits and hyporeflective
