Ruchira Singh

Ruchira Singh

Company: University of Rochester

Job title: Associate Professor, Department of Ophthalmology

Seminars:

Patient-Derived iPS Cell Model of Macular Degeneration: Disease Mechanisms & Potential Therapeutics 3:15 pm

iPSC models of both AMD and related macular dystrophies recapitulate key maculopathy phenotypes In the iPSC model of multiple maculopathies – perturbation in TIMP3-MMP axis precedes pathological changes Excess TIMP3 and consequently reduced levels of RPE-secreted MMP2 lead to pro-maculopathy cellular changesRead more

day: Day One

Panel Discussion – Reviewing the Current State of Dry AMD Preclinical Models & What the Future Looks Like? 12:45 pm

Brief overview of blue light, sodium iodate and mass cell degranulation models to set the context for this session Discussing the qualities of the ideal preclinical model to identify key areas of development Looking towards the next generation of animal models as for better recapitulation of human dry AMDRead more

day: Day One

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