Patient-Derived iPS Cell Model of Macular Degeneration: Disease Mechanisms & Potential Therapeutics
Time: 3:30 pm
day: Day One
Details:
- iPSC models of both AMD and related macular dystrophies recapitulate key maculopathy phenotypes
- In the iPSC model of multiple maculopathies – perturbation in TIMP3-MMP axis precedes pathological changes
- Excess TIMP3 and consequently reduced levels of RPE-secreted MMP2 lead to pro-maculopathy cellular changes
