Patient-Derived iPS Cell Model of Macular Degeneration: Disease Mechanisms & Potential Therapeutics

Time: 3:30 pm
day: Day One


  • iPSC models of both AMD and related macular dystrophies recapitulate key maculopathy phenotypes
  • In the iPSC model of multiple maculopathies – perturbation in TIMP3-MMP axis precedes pathological changes
  • Excess TIMP3 and consequently reduced levels of RPE-secreted MMP2 lead to pro-maculopathy cellular changes