On the Horizon – HtrA1 Inhibition in the Treatment of GA
Time: 1:30 pm
day: Track 1 Day 2 PM
Details:
- Strong human genetic evidence associates ocular HtrA1 overexpression with geographic atrophy and all neovascular forms of AMD
- Growing understanding of how HtrA1 substrates and products play important roles in the pathogenesis of AMD
- Compelling preclinical and clinical evidence for role of HtrA1 in AMD
- HtrA1 pathway is non-overlapping with VEGF and is independent of complement risk factors
