On the Horizon – HtrA1 Inhibition in the Treatment of GA

Time: 1:30 pm
day: Track 1 Day 2 PM


  • Strong human genetic evidence associates ocular HtrA1 overexpression with geographic atrophy and all neovascular forms of AMD
  • Growing understanding of how HtrA1 substrates and products play important roles in the pathogenesis of AMD
  • Compelling preclinical and clinical evidence for role of HtrA1 in AMD
  • HtrA1 pathway is non-overlapping with VEGF and is independent of complement risk factors